diff --git a/direnvrc b/direnvrc
index d153bd7..4fe7708 100644
--- a/direnvrc
+++ b/direnvrc
@@ -86,6 +86,13 @@ _nix_add_gcroot() {
   ln -fsn "$symlink" "/nix/var/nix/gcroots/per-user/$USER/$escaped_pwd"
 }
 
+_argsum_suffix() {
+  if [ -n "$1" ]; then
+    echo -n "-"
+    echo "$1" | shasum | cut -d' ' -f1
+  fi
+}
+
 use_flake() {
   flake_expr="${1:-.}"
   flake_dir="${flake_expr%#*}"
@@ -94,7 +101,7 @@ use_flake() {
 
   local layout_dir
   layout_dir=$(direnv_layout_dir)
-  local profile="${layout_dir}/flake-profile"
+  local profile="${layout_dir}/flake-profile$(_argsum_suffix "$flake_expr")"
   local flake_inputs="${layout_dir}/flake-inputs/"
   local profile_rc="${profile}.rc"
 
@@ -209,7 +216,7 @@ use_nix() {
     version="${version_prefix}-${path:11:16}"
   fi
 
-  local cache="${layout_dir}/cache-${version:-unknown}"
+  local cache="${layout_dir}/cache-${version:-unknown}$(_argsum_suffix "$*")"
 
   local update_drv=0
   if [[ ! -e "$cache"